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ASNM Member Commentary

Kuan Wang  PhD
Director of Nanomedicine Program
Institute of Biological Chemistry & Institute of Physics

Dr.  Kuan  Wang  is  currently  Director  of  Nanomedicine  Program  and  Distinguished  Research  Fellow  of  Institute  of   Biological  Chemistry  and  Institute  of  Physics,  Academia  Sinica,  Taiwan.  He  was  the  Lab  Chief  of  the  Laboratory  of  Muscle   Biology  and  Section  Head  of  the  Muscle  Proteomics  and  Nanotechnology  Section  at  the  National  Institute  of  Arthritis   and  Musculoskeletal  and  Skin  Diseases,  NIH  until  August  2010.     Dr.  Wang  is  one  of  the  founding  members  of  the  American  Society  for  Nanomedicine  and  is  currently  serving  as  a   member  of  the  Board  of  Directors.  

 

 Dr.  Wang  has  made  significant  contributions  to  the  study  of  muscle  biology  and  cell  motility,  including  the  discovery  and   naming  of  five  new  cytoskeletal  proteins  (filamin,  titin,  nebulin,  P235  (talin)  and  nebulette)  important  in  assembly,   regulation  and  dysfunction  of  the  cytomatrix  in  cardiac,  skeletal  and  smooth  muscles  and  in  non-­‐muscle  cells.  Dr.  Wang’s   discovery  of  a  giant  elastic  protein  titin,  the  largest  protein  in  human  genome,  led  to  a  whole  field  of  inquiries,  including   the  elasticity  in  protein  function,  the  mechanical  stress  sensing  and  transduction  in  cellular  signaling  and  the  interplay   between  mechanical  force  and  molecular  interactions.     Under  Dr.  Wang’s  mentoring  at  Academia  Sinica,  Taiwan  a  team  of  biologists,  chemists,  engineers,  and  physicists  work   together  closely  with  collaborators  at  other  institutions  to  develop  new  therapeutics  and  drug  delivery  techniques.    





 
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